OUR REVIEWS
100% natural, chemical-free, and works with your body’s own biology

PRF Skin Rejuvenation in Indianapolis — Natural Collagen Renewal

At MD Wellness Center & Med Spa, we use Platelet-Rich Fibrin (PRF) — the next generation of PRP (Platelet-Rich Plasma) — to help your skin renew itself naturally. While both treatments use your own blood to harness growth factors and stimulate collagen, PRF delivers a higher concentration of platelets and stem cells, resulting in smoother texture, improved tone, and long-lasting rejuvenation.

All aesthetic injection treatments are performed exclusively by our MD to ensure precision, safety, and consistency in your results.

Treats

  • Fine LInes + Wrinkles
  • Crepey or Sagging Skin
  • Under-eye Hollowness
  • Uneven Skin Tone + Texture
Reviews
900+ reviews
The doctor was super honest about what to expect. I’m doing PRF and laser and loving the results so far.
Amanda S ★ ★ ★ ★ ★
He's extremely careful and caring when injecting, and he made the experience as easy as possible for someone with needle-phobia.
Mikaili Azziz ★ ★ ★ ★ ★
You're definitely in good hands here. Got microneedling with prp for acne scars and looking into hair restoration treatments with prp as well.
Devon Romano ★ ★ ★ ★ ★
I wanted an alternative to normal filler, PRF seemed like the most natural way to go. Pricing was comprable too!
Estrada K ★ ★ ★ ★ ★

Pricing

Starts at $749

Restore your skin’s radiance from within.

PRF Skin Rejuvenation

What It Is
Platelet-Rich Fibrin (PRF) is an advanced regenerative treatment that uses your own blood to create a serum rich in platelets, stem cells, and growth factors — key components that trigger collagen and elastin production for firmer, smoother skin.

How It Works
A small sample of blood is drawn and spun at a low speed to create a golden fibrin matrix packed with platelets and stem cells. This concentrated serum is then applied or injected into targeted areas of the face — such as the under-eyes, cheeks, or around fine lines — where it stimulates new collagen, improves texture, and enhances elasticity over time.

PRF vs. PRP
Both treatments harness your platelets for skin rejuvenation, but PRF is processed more gently, preserving more white blood cells and stem cells. This allows for slower release and longer-lasting results, giving you a more youthful, natural glow.

What to Expect

Your PRF session begins with a quick blood draw, followed by gentle preparation of the platelet-rich fibrin serum. Depending on your treatment plan, PRF may be injected into fine lines or under-eye areas or combined with microneedling to boost collagen production across the face.

  • Treatment Time: 45–60 minutes

  • Downtime: Minimal — mild redness for 24–48 hours

  • Results: A natural glow within days; continued collagen renewal for 4–6 weeks

  • Series: Most patients benefit from 3 sessions, spaced 4–6 weeks apart

This treatment can also be combined with RF Microneedling or dermal fillers for enhanced volume and tightening.

Next Steps

We recommend starting with a free aesthetic consultation to evaluate your skin tone, discuss your goals, and determine if PRF is the right fit for you.

Serving Indianapolis, Carmel, Fishers, and surrounding areas
Call 317-548-4666 or click below to schedule your consultation at MD Wellness Center & Med Spa today.

Online Scheduling

About Us

Indy’s Leading Provider of Non-Surgical Aesthetic Treatments

At MD Wellness Center & Med Spa, PRF and PRP treatments are performed by experienced aesthetic professionals under the supervision of Dr. Srinivasu Kesa, MD, a licensed physician with more than 30 years of medical experience and advanced training in aesthetic injectables, lasers, and regenerative skin therapies.

Our team’s focus is on delivering natural, healthy-looking results — using your body’s own regenerative power to restore confidence in your skin.

  • Physician-supervised regenerative care

  • Safe, all-natural collagen stimulation

  • Personalized protocols for your skin’s needs

  • Combination therapies for next-level rejuvenation

Frequently Asked Questions

What makes PRF different from PRP?

Both PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin) harness your body’s natural healing power to restore and rejuvenate the skin. The key difference is that PRF is processed at a lower centrifuge speed, allowing it to retain more white blood cells, stem cells, and a fibrin matrix that slowly releases growth factors over time. This leads to longer-lasting and more natural results compared to PRP.

Is PRF safe?

How soon will I see results from PRF?

Is there any downtime after PRF treatment?

How long do PRF results last?

Who is a good candidate for PRF skin rejuvenation?

Can PRF be combined with other skin treatments?

Customer Reviews

Total Reviews

900+
★★★★★

I like that he as a doctor, MD, does the injections. I have been to other places that nurses do them and have not been happy with the results. I’m always happy with Dr.K. He is patient and understanding. He listens to what i’m trying to achieve. He also tells me honestly what can be done and what can’t. I do not want to have a facelift or any invasive surgeries so he is very honest with me what kind of results I can expect with the minimal or non invasive procedures.

Laura Jean

★★★★★

I wanted an alternative to normal filler, PRF seemed like the most natural way to go. Pricing was comprable too! Easy and great results

Estrada K

★★★★★

I got recommendation from my family about this place. Staff is excellent and the service is phenomenal. You’re definitely in good hands here. Got microneedling with prp for acne scars and looking into hair restoration treatments with prp as well.

Devon Romano

★★★★★

I went here to get tear trough/under eye fillers done for the first time. I was so nervous that I was shaking– and Dr. Kesa offered me stress balls, which helped tremendously. He’s extremely careful and caring when injecting, and he made the experience as easy as possible for someone with needle-phobia. It will take a week or two to see my final results but I love them so far! Will be returning!

Mikaili Azziz

★★★★★

The doctor was super honest about what to expect. I’m doing PRF and laser and loving the results so far.

Amanda S

Why Choose us

MD Wellness Center and Med Spa

  • Medical Expertise by Dr. Kesa
  • 900+ Verified 5-Star Reviews
  • Comprehensive Aesthetic & Wellness Services
  • Conveniently Located in Indianapolis
  • Virtual & In-Clinic Consultations Available

Contact Us

Our team is here to help you make an appointment with the specialists that you need: call us or fill the online booking form

Phone Number

317-548-4666

Address

6822 E 82nd Street #310, Indianapolis IN 46250


Email

contact@mytrimmd.com

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Proudly Serving Indianapolis, Carmel, Fishers, Noblesville And Surrounding Areas

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*Disclaimer: The information on this website is provided for general informational and educational purposes only and is not intended as medical advice. Content on this site is not a substitute for professional diagnosis, treatment, or medical decision-making.

*Photos and testimonials are for illustrative purposes only. Individual results vary.